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[Dunia] Neuroscientists Detect Confused 'Zombie' Cells in The Human Brain After Death

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Author: sarah82    From the mobile phone    Show all posts   Read mode

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Post time 3-5-2021 10:15 PM From the mobile phone | Show all posts |Read mode
Edited by sarah82 at 3-5-2021 10:17 PM

TESSA KOUMOUNDOUROS
24 MARCH 2021
You'd think once a human is dead, the body would be done doing things; without blood circulation and air, the inner systems would be fast depleted. But due to a weird quirk of biology there are such things as the living dead - living cells, at least, within a done and dusted body.

Some cells within human brains actually increase their activity after we die. These 'zombie' cells ramp up their gene expression and valiantly continue trying to do their vital tasks, as if someone forgot to tell them they're now redundant.

Neurologist Jeffrey Loeb from the University of Illinois and colleagues watched as these cells stubbornly sprouted new tentacles and busied themselves with chores for hours after death.

"Most studies assume that everything in the brain stops when the heart stops beating, but this is not so," Loeb said. "Our findings will be needed to interpret research on human brain tissues. We just haven't quantified these changes until now."

Much of the information we have on brain disorders like autism, Alzheimer's, and schizophrenia, comes from experiments performed on brain tissues after death; this approach is critical in the search for treatments, as animal models for brain studies often fail to translate back to us.

Usually, this work is done on tissues from people who've died more than 12 hours ago. By comparing gene expression in fresh brain tissues (removed as part of epilepsy surgery from 20 patients) to aforementioned brain samples from deceased people, Loeb and team found striking differences that were not age nor disease specific.

They used data on gene expression, which they later corroborated by examining the brain tissue's histology, to understand cell-specific activity changes across time since death, at room temperature.

While most gene activity remained stable for the 24 hours the team documented, neuronal cells and their gene activity rapidly depleted. Most remarkably though, glial cells increased gene expression and processes.

zombiecells_brain_body_.jpg
Cells come to life after death of the human brain. (Dr. Jeffrey Loeb/UIC

While surprising at first, this actually makes a lot of sense, given glial cells, such as waste-eating microglia and astrocytes, are called into action when things go wrong. And dying is about as 'wrong' as living things can go.

"That glial cells enlarge after death isn't too surprising given that they are inflammatory and their job is to clean things up after brain injuries like oxygen deprivation or stroke," said Loeb.

The team then demonstrated the RNA expressed by genes doesn't itself change within 24 hours post death, so any changes in its amount must indeed be due to the continuation of biological processes.

While most gene activity remained stable for the 24 hours the team documented, neuronal cells and their gene activity rapidly depleted. Most remarkably though, glial cells increased gene expression and processes.

"The complete gene expression of freshly isolated human brain samples allows an unprecedented view of the genomic complexity of the human brain, because of the preservation of so many different transcripts no longer present in postmortem tissues," the researchers wrote in their paper.

This has huge implications for both past and present studies using brain tissue to understand diseases that involve immune responses - such as these 'zombie' glial cells that swell as they futilely devour surrounding bits of dying brains.

After 24 hours, however, these cells also succumbed and were no longer distinguishable from the degrading tissue that surrounded them.

"Researchers need to take into account these genetic and cellular changes, and reduce the post-mortem interval as much as possible to reduce the magnitude of these changes," Loeb explained.
"The good news from our findings is that we now know which genes and cell types are stable, which degrade, and which increase over time so that results from postmortem brain studies can be better understood."
Even in death, we biological entities are never entirely static.
This research was published in Scientific Reports.

SUMBER : https://www.sciencealert.com/confused-zombie-cells-spring-to-action-after-a-human-brain-die

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Post time 3-5-2021 10:29 PM From the mobile phone | Show all posts
Takkan la sekarang baru jumpe kot..  Jaman Julius Caesar lagi dah ade postmortem.  Sedey..
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 Author| Post time 3-5-2021 10:29 PM From the mobile phone | Show all posts
tumpanglalu74 replied at 3-5-2021 10:29 PM
Takkan la sekarang baru jumpe kot..  Jaman Juliua Caesar lagi dah ade postmortem.  Sedey..

Aku baca tadi mmg baru jumpa.. Tu aku sharw.. Hahahaa.
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Post time 3-5-2021 11:07 PM From the mobile phone | Show all posts
Edited by terma2nkondisi2 at 3-5-2021 11:09 PM

cite zombie best yg underated

kelakar yg sempoi

Warm Bodies (2013)
https://m.imdb.com/title/tt01588173/

sori tt... mencelah sikit
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 Author| Post time 4-5-2021 12:16 AM From the mobile phone | Show all posts
terma2nkondisi2 replied at 3-5-2021 11:07 PM
cite zombie best yg underated

kelakar yg sempoi

Wahhhh.. Kena tengok ni..
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Post time 4-5-2021 12:31 AM From the mobile phone | Show all posts
sarah82 replied at 4-5-2021 12:16 AM
Wahhhh.. Kena tengok ni..

Allah Ada sebut x zombie dlm Al-Quran???

Kot2 konspirashit
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Post time 4-5-2021 12:32 AM From the mobile phone | Show all posts
sarah82 replied at 4-5-2021 12:16 AM
Wahhhh.. Kena tengok ni..

yup... memang kena tengok... dah lama dah cite ni tapi masih teringat2 lagi citenye sbb cite ni cite zombi lain dari yg lain

romantic comedy yg bersahaja... santai... tak over.. tapi storyline yg bagus walaupun bukan movie yg jenis berat dan deep sangat..

imdb rating tu terma rasa patut sekurang2nya 7... maybe 7.1 ke 7.2 ke

ape2 pun, best cite ni dan bukan zombie movie yg tipikal
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 Author| Post time 4-5-2021 12:38 AM From the mobile phone | Show all posts
terma2nkondisi2 replied at 4-5-2021 12:32 AM
yup... memang kena tengok... dah lama dah cite ni tapi masih teringat2 lagi citenye sbb cite ni ci ...

Cun sangat ni.. Nak kena layan..
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Post time 4-5-2021 12:40 AM From the mobile phone | Show all posts
terma2nkondisi2 replied at 4-5-2021 12:32 AM
yup... memang kena tengok... dah lama dah cite ni tapi masih teringat2 lagi citenye sbb cite ni ci ...

Sebab ceta ni la lagu hungry heart Billy Joel masuk Dalam my favourite songs
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Post time 4-5-2021 01:39 AM From the mobile phone | Show all posts
cite zombie yg paling best penah iols tgok world war z.. mmg 2 jam lebih tu penuh action jer x boring pun..
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 Author| Post time 4-5-2021 02:14 AM From the mobile phone | Show all posts
haifawehbe replied at 4-5-2021 01:39 AM
cite zombie yg paling best penah iols tgok world war z.. mmg 2 jam lebih tu penuh action jer x borin ...

wwZ mmg Best... Tgg juga kot2 keluar lagi next film
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Post time 4-5-2021 02:44 AM From the mobile phone | Show all posts
terma2nkondisi2 replied at 3-5-2021 11:07 PM
cite zombie best yg underated

kelakar yg sempoi

Yeap. Cite ni memang best.
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Post time 4-5-2021 03:04 AM From the mobile phone | Show all posts
terma2nkondisi2 replied at 3-5-2021 11:07 PM
cite zombie best yg underated

kelakar yg sempoi

iol suka yang ini ...
Scout guide to the zombie apocalypse
tgk dah?
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Post time 4-5-2021 03:07 AM From the mobile phone | Show all posts
TT rasa tak Frankenstein tu sebenarnya zombie?
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 Author| Post time 4-5-2021 03:14 AM From the mobile phone | Show all posts
lavendernovella replied at 4-5-2021 03:07 AM
TT rasa tak Frankenstein tu sebenarnya zombie?

Rasanya.. Sbb kalau ikut citer Frankenstein.. Dia dari gabungan bbrp bahagian manusia yg berlainan dan hidup bila kilat @ kuasa elektrik yg berkuasa tinggi disalurkan ke badan dia.
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Post time 4-5-2021 03:38 AM From the mobile phone | Show all posts
Boleh try tengok filem zombie for sale jugak
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 Author| Post time 4-5-2021 04:29 AM From the mobile phone | Show all posts
kam3n replied at 4-5-2021 03:38 AM
Boleh try tengok filem zombie for sale jugak

Wahhh.. Byk citer zombie Best2 rupanya.. Kena cari ni.. Hihihi
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Post time 4-5-2021 05:25 AM From the mobile phone | Show all posts
Otak tgh busy menjawab mungkar nakir kot. Sampai jadi zombie ha ha. Tapi kejap, selagi tak masuk kubur, mungkar nakir tak pay a visit yet kan? Ke, regardless where even on the postmortem table in the labs, after a while they will come knocking?
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 Author| Post time 4-5-2021 06:35 AM From the mobile phone | Show all posts
mclaren replied at 4-5-2021 05:25 AM
Otak tgh busy menjawab mungkar nakir kot. Sampai jadi zombie ha ha. Tapi kejap, selagi tak masuk kub ...

Rasanya bila masuk dlm liang lahad.. Bila semua dah tinggalkan perkuburan.. Baru mungkar nakir dtg.. Tak salah iols.
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Post time 4-5-2021 07:15 AM From the mobile phone | Show all posts
While surprising at first, this actually makes a lot of sense, given glial cells, such as waste-eating microglia and astrocytes, are called into action when things go wrong. And dying is about as 'wrong' as living things can go.


Mesti clan sel nih ckp weiiii apsal makin byk plak ne sapu neh ahahaaa sian theyols umpama basuh pinggan/cwn di hari raya wout kobid kohkoh

Naisss sharing tt.. nampak nau u betholl2 zombie lover
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